Prescribing just got safer

API Query

https://api.drugbank.com/v1/ddi?drugbank_id=DB00316,DB00682

{
  "interactions": [
    {
      "ingredient": {
        "drugbank_id": "DB00316",
        "name": "Acetaminophen"
      },
      "affected_ingredient": {
        "drugbank_id": "DB00682",
        "name": "Warfarin"
      },
      "description": "The risk or severity of adverse effects can be increased when Acetaminophen is combined with Warfarin.",
      "extended_description": "Chronic oral acetaminophen use at a dose of 4,000 mg/day has been demonstrated to cause an increase in the international normalized ratio (INR) for some patients who have been stabilized on sodium warfarin as an anticoagulant. This interaction is thought to occur through augmented effects on vitamin K antagonism, increasing the risk of bleeding.",
      "action": "increase_adverse_effects",
      "severity": "moderate",
      "subject_dosage": null,
      "affected_dosage": null,
      "evidence_level": "level_1",
      "management": "Use this combination with caution. Avoid warfarin doses of 4, 000 mg/day or higher when acetaminophen is used, and regularly monitor INR. Adjust drug dosage as necessary, according to clinical response."
    }
  ],
  "total_results": 1
}